Mercoledì 12 Marzo 2025 alle ore 16:30 (CET), nel quadro del ciclo di seminari Insalate di Matematica, Sofia Tonali (Università degli Studi di Pavia) parlerà di
Titolo: Mathematical modeling of Multielectrode Arrays with Pluripotent Stem Cell-Derived Cardiomyocytes
Abstract: After their discovery, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are transforming cardiac research, offering patient-specific alternatives for studying heart physiology and diseases. However, their electrical behavior differs from adult heart cells, making mathematical modeling crucial for understanding their properties.
In this talk, a new in silico model, based on partial differential equations, will be presented. This model simulates the electrical activity of hiPSC-CMs and their interaction with microelectrode arrays (MEA), a non-invasive tool that records extracellular signals. The model captures key electrophysiological phenomena, from action potential propagation to conduction velocity, bridging the gap between intracellular dynamics and MEA recordings. Numerical results to illustrate the model in action and its potential applications will also be presented.
Keywords: hiPSC-CMs & cardiac dynamics, Partial differential equations, Bidomain model, Numerical simulations
Informazioni per partecipare
Il seminario si terrà in Aula 3014 (3° Piano) - Edificio U5, Università degli Studi di Milano-Bicocca e sarà possibile partecipare anche online da questo link (password: insalate, 46725283 from phones)
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