Wednesday 12 March 2025 at 4:30 pm (CET), as part of the Insalate di Matematica seminar cycle, Sofia Tonali (University of Pavia) will talk about
Title: Mathematical modeling of Multielectrode Arrays with Pluripotent Stem Cell-Derived Cardiomyocytes
Abstract: After their discovery, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are transforming cardiac research, offering patient-specific alternatives for studying heart physiology and diseases. However, their electrical behavior differs from adult heart cells, making mathematical modeling crucial for understanding their properties.
In this talk, a new in silico model, based on partial differential equations, will be presented. This model simulates the electrical activity of hiPSC-CMs and their interaction with microelectrode arrays (MEA), a non-invasive tool that records extracellular signals. The model captures key electrophysiological phenomena, from action potential propagation to conduction velocity, bridging the gap between intracellular dynamics and MEA recordings. Numerical results to illustrate the model in action and its potential applications will also be presented.
Keywords: hiPSC-CMs & cardiac dynamics, Partial differential equations, Bidomain model, Numerical simulations
Information to attend
The seminar will be held in Room 3014 (3rd Floor) - U5 Building, University of Milano-Bicocca and will also be available online by this link (password: insalate, 46725283 from phones)
For more information, visit the website